According to a recently published study from the Brigham and Woman’s Hospital, mesenchymal stem cells [MSCs] have the ability to reverse type I diabetes by suppressing the auto-immune attack of islet cells. Although the MSCs cannot be directly injected into the pancreas, the researchers utilized the surface adhesion molecule HCELL to hone the stem cells in on the inflamed islets, allowing them to normalize blood sugar levels without the use of insulin. Continue reading
Researchers led by Dr. Habib Zaghouani from the University of Missouri have developed a potential cure to Type 1 Diabetes by utilizing mesenchymal stem cells [MSCs]. Although researchers anticipated that the MSCs would differentiate into new insulin producing pancreatic beta cells, they discovered that the stem cells fulfilled the more critical function of repairing damaged blood vessels, which in turn facilitated the regeneration of insulin producing pancreatic beta cells and the distribution of insulin across the body. Continue reading
Researchers from the Gladstone Institutes have developed a potential treatment for Type 1 diabetes by differentiating stem cells into insulin-producing pancreatic beta cells. These new cells, when transplanted into animal models, lowered abnormally high glucose levels down to a more healthy level in just one week. Continue reading
As reported by the Wall Street Journal, adult stem cell therapies are advancing rapidly; with researchers utilizing stem cells to treat an expanding range of disease, trauma and injury. The article highlights the increasing use of cord blood to treat a variety of ailments such as; Cerebral Palsy, Traumatic Brain Injury and immune deficiencies such as diabetes. Continue reading
Millions of individuals around the world suffer from type-1 diabetes, three million in the US alone. Researchers at the University of Missouri, led by Dr. Habib Zaghouani, have developed a two pronged approach to curing the disease: they modulate the immune system with a drug that stops it from attacking the pancreas and use stem cells to regenerate and rebuild the insulin producing pancreatic beta cells.
Scientists at the Walter and Eliza Hall Institute recently discovered that the pancreas contains stem cells that can be turned into insulin-producing cells. This new research provides hope that patients who currently suffer from type 1 diabetes may one day be able to regrow their own insulin producing pancreatic beta cells. Researchers are thus turning to stem cells to address a defining aspect of Type 1 Diabetes – the destruction of the pancreas while also seeking ways to modulate the patient’s immune system to prevent it from destroying the new, regenerated pancreatic tissue.
Timothy Kieffer, Professor of Cellular and Physiological Sciences at the University of British Columbia [UBC], in conjunction with scientists from the New Jersey-based BetaLogics, recently put out research demonstrating that human stem cell transplants can successfully restore insulin production and reverse diabetes in mice.
In a demonstration of the expanded the use of stem cells in novel ways, researchers at the City of Hope Medical Research Center in Duarte, California, have developed a treatment approach that may effectively cure Type 1 diabetes. In this study, researchers utilized stem cells to both initiate regeneration of pancreatic β cells as well moderate the immune system to prevent the destruction of the pancreas.