Jackson Laboratory scientists have identified the adult lung stem cells p63+/Krt5+ as the specific cell line that specializes in lung regeneration. In an animal model, professors Frank McKeon, Ph.D. and Wa Xian, Ph.D. observed as the p63+/Krt5+, which typically mature into the lungs’ alveoli, responded to lung damage caused by the H1N1 influenza virus by migrating to the sites of inflammation and restoring the lost tissue. Continue reading
Researchers at the Samsung Medical Center and Biomedical Research Institute in Seoul, South Korea, have succeeded in treating and preventing Bronchopulmonary Dysplasia [BPD], a chronic lung disease affecting preterm infants. In a Phase 1 clinical trial, the research team was successful in transplanting mesenchymal stem cells to repair damage and underdevelopment within the infant’s lungs. Continue reading
Columbia University researchers have developed a method to differentiate stem cells into functional lung and airway cells. The technique, the first of its kind, represents a significant advance in the development of personalized treatments for patients suffering from a variety of lung issues.<!–more–>
Co-author of the paper, Dr. Gordana Vunjak Novakovic, PhD, [who also serves as member of StemSave’s Scientific Advisory Council], believes that the method, utilizing a patient’s own stem cells, could pave the way for generating lung grafts that avoid the risk of rejection during transplantation. The ability to regenerate lung cells also enables researchers to better study and understand lung diseases thereby accelerating the development of more effective treatments.
Innovative research such as this demonstrates the integral role stem cell therapies will soon play in cutting edge medical care options. By banking their own valuable stem cells, families can ensure that they will have access to these emerging therapies in the near future. To learn more about banking stem cells, please visit <a href=”www.stemsave.com”>www.stemsave.com </a>or call 877-783-6728 (877-StemSave) today.
To view the full article, <a href=”http://newsroom.cumc.columbia.edu/blog/2013/12/01/human-stem-cells-converted-functional-lung-cells/”>click here</a>.
The Future of Regenerative Medicine is Now™
Nearly half a million babies in the U.S. are born premature every year (that’s roughly 1 in every 8 children). Many of them require medical assistance during the first weeks of life, especially due to their under-developed lungs. Babies that are born premature are often put on breathing machines as their lungs finish maturing, but there can be negative side effects of these measures: many children (as many as 10,000) develop a condition called bronchopulmonary dysplasia, or BPD.
But research headed by Bernard Thébaud, a neonatologist and senior scientist at the Ottawa Hospital Research Institute and CHEO Research Institute, demonstrates that mesenchymal stem cells (MSCs) can help repair damaged lungs in animal studies involving newborn rats, which have lungs that are roughly similar to a human fetus at 24 weeks of development.