According to new research from the National Yang-Ming University, mesenchymal stem cells [MSCs] hold the ability to limit atherosclerotic plaque formation, thereby preventing the onset of harmful endothelial lesions. The research team, led by Shih-Chieh Hung, transplanted MSCs into animal models with atherosclerosis and observed significant reduction in plaque formation. They also saw an increase in blood vessel dilation, which prevents further plaque development, indicating good endothelial health. Continue reading
Researchers at the University Of Maryland School Of Medicine have created a pulmonary valve replacement for pediatric patients suffering from congenital heart conditions. The scientists, led by Dr. David L. Simpson, differentiated the patient’s own [autologous] stem cells into heart valvular cells and then arranged these cells to bioengineer a pulmonary valve that was unique to each patient. The valve was created in vitro [outside the body] so the next step would be to develop protocols to undertake clinical trials. Continue reading
Researchers led by Dr. Habib Zaghouani from the University of Missouri have developed a potential cure to Type 1 Diabetes by utilizing mesenchymal stem cells [MSCs]. Although researchers anticipated that the MSCs would differentiate into new insulin producing pancreatic beta cells, they discovered that the stem cells fulfilled the more critical function of repairing damaged blood vessels, which in turn facilitated the regeneration of insulin producing pancreatic beta cells and the distribution of insulin across the body. Continue reading
The Cardiovascular Research Foundation will be hosting the Ninth International Conference on Cell Therapy for Cardiovascular Disease from January 22nd to 24th, 2014. The conference will cover major preclinical and clinical studies, as well as the promising stem cell-based products and therapies being developed to treat cardiovascular disease. Continue reading
Duchenne Muscular Dystrophy, a particularly severe form of muscular dystrophy [MD – a genetic disorder], affects as many as 15,000 young Americans. Many of those afflicted eventually succumb to cardiac or respiratory failure by their early 20’s. Researchers at University of California, Los Angeles, are utilizing stem cells to model the disease in order to develop and test treatments. One particularly promising treatment involves a method referred to as exon skipping. The technique essentially tricks the cell’s machinery into misreading the MD genetic mutation so instead of producing the defective protein responsible for the disease, the cells produce a more functional version of the protein. In using muscle cells derived from stem cells of people with muscular dystrophy – the cells contain the mutation that causes muscular dystrophy – researchers anticipate their tests to more accurately reflect how human cells would react to their drugs [or combination of drugs]. This enables more efficient and effective testing of potential treatments and speeds the process of developing those treatment options that show the most promise. According to Stanley Nelson, a lead researcher on the project, “We are thrilled that stem cell research will change the outcome of Duchenne”.
- A cross-section of a brain-like clump of neural cells derived from stem cells
Researchers at the Austrian Academy of Science, Institute of Molecular Biotechnology in Vienna have developed brain-like chunks of tissue utilizing human stem cells. This advance in stem cell differentiation will give researchers a better understanding of brain development, which will accelerate stem cell treatments for brain related disorders.
The research is an example of how scientists are gaining insights that will facilitate more effective regenerative treatments leading to better outcomes. To learn more about the value of preserving your own stem cells for use in future regenerative therapies and how to bank your own stem cells through a non-evasive and affordable method by recovering your dental pulp stem cells, visit StemSave or call 877-783-6728 (877-StemSave) today.
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Researchers at UMass Medical School use human stem cells to ‘shut down’ the chromosomes causing Down syndrome. The lead researcher, Jeanne B. Lawrence, a professor of cell and developmental biology at UMass Medical School, explained, “Our hope is that for individuals living with Down syndrome, this proof-of-principal opens up multiple exciting new avenues for studying the disorder now, and brings into the realm of consideration research on the concept of ‘chromosome therapy’ in the future”. The treatment seeks to address the root cause of the disease as opposed to merely mitigating the symptoms of the disease.
In an early stage study recently carried out by the Institute of Kidney Diseases and Research Center (IKDRC), a treatment developed by the IKDRC utilizing Insulin Secreting Cells (ISC), derived from the patient’s own mesenchymal stem cells, shows that the need for insulin doses decreased by an average of 50% when the ISCs were implanted in patients.
Researchers at Yokohama City University in Japan created tiny human livers utilizing human stem cells. The rudimentary livers [which were transplanted into mice] grew, made human liver proteins, and metabolized drugs as human livers do. And while the liver buds, as they are called, did not turn into complete livers, the study represents an important step in developing methodologies for growing large, complex organs.
In a novel use of stem cells, scientists at Rockefeller University and The Scripps Research Institute have created what they are referring to as a ‘humanized mouse’, which responds to diseases as a human would. The creation of mice that react to disease and potential treatments the way humans would will significantly reduce the cost, and speed the process, of developing treatments for a wide variety of disease. “We believe this will improve drug discovery because the reactions we observed were authentic human reactions,” says Dr. Harris Perlman of Northwestern University Feinberg School of Medicine. Some of the diseases researchers are using these modified mice to develop treatments for are Rheumatoid Arthritis (RA) – an affliction that affects 70 million people (worldwide) and the Hepatitis C Virus (HCV) which affects 130 million people worldwide.