Multiple Sclerosis Treatment Becomes Canada’s First MS Stem Cell Clinical Trial.

The University of Ottawa trial infuses MSCs to reduce inflammation in the central nervous systems of MS patients.

The Multiple Sclerosis Society of Canada has funded Canada’s first stem cell clinical trial to treat multiple sclerosis, conducted by researchers at the University of Ottawa. The trial, called MESCAMS [Mesenchymal Stem Cell Therapy for Canadian MS patients], will comprise MSC infusions to the central nervous system to utilize their ability to regulate autoimmune attacks and reduce inflammation in 40 MS patients. Continue reading

An Eye for a Tooth: Corneal Blindness Treatment Advances With The Use Of Dental Stem Cells.

Dental Stem Cells may hold the potential to cure corneal blindness.

Ophthalmologists James L Funderburgh, Ph.D. and Fatima Syed-Picard, Ph.D. from the University of Pittsburgh have devised a method for treating corneal blindness by utilizing dental pulp stem cells.  The researchers harvested the stem cells from molars discarded during routine extraction and induced the cells to differentiate into keratocytes [corneal cells].  They then seeded the cells onto a nanofiber scaffold, allowing them to grow into fully developed, functional corneas capable of restoring eyesight.    Continue reading

Hypoplastic Left Heart Syndrome Treatment Integrates Cardiac Stem Cells.

Initial trials of stem cell treatment for hypoplastic left heart syndrome have proven to be both safe and effective for children with the congenital defect.

Researchers from Okayama University have developed a method to treat the congenital heart defect known as hypoplastic left heart syndrome [HLHS] by utilizing a specialized cardiac stem cell.  In a Phase I clinical trial conducted on children suffering from HLHS, the scientists concluded that, because the young stem cells in children are more abundant and self-renewing than those in adults, intracoronary injection of stem cells is a safe and feasible approach to treating the condition. Continue reading

Stroke-Induced Brain Damage Prevented by Stem Cells.

Stem cells have been found to prevent neurological damage to GCI stroke victims.

In a recently published study from the Hallym University College of Medicine, researchers have applied mesenchymal stem cells [MSCs] to animal models afflicted with global cerebral ischemia [GCI] to successfully reduce the associated neuronal damage.  When compared to those that received no treatment, animals that received MSCs displayed a significant decrease in cell death, inflammation to the brain, and disruption of the blood brain barrier. Continue reading

Atherosclerotic Lesions Prevented by MSCs

Stem cells were found to reduce plaque in patients with atherosclerosis.

According to new research from the National Yang-Ming University, mesenchymal stem cells [MSCs] hold the ability to limit atherosclerotic plaque formation, thereby preventing the onset of harmful endothelial lesions. The research team, led by Shih-Chieh Hung, transplanted MSCs into animal models with atherosclerosis and observed significant reduction in plaque formation. They also saw an increase in blood vessel dilation, which prevents further plaque development, indicating good endothelial health. Continue reading

Sniffing Out Parkinson’s Disease With Stem Cells

Stem Cells found in the nose produce neurons that may be able to treat neurodegenerative diseases.

German scientists at the University of Bielefeld and Dresden University of technology have produced neurons from inferior turbinate stem cells [ITSC], a cell type that is typically discarded during sinus surgery, as a potential treatment for Parkinson’s disease.  After transplanting the ITSCs into an animal model suffering from Parkinson’s, the researchers observed full functional restoration and significant behavioral recovery in the subjects without any adverse side effects. Continue reading

Lung Regeneration Made Possible through Stem Cells.

Scientists have found a stem cell line that specializes in restoring lung tissue

Jackson Laboratory scientists have identified the adult lung stem cells p63+/Krt5+ as the specific cell line that specializes in lung regeneration.  In an animal model, professors Frank McKeon, Ph.D. and Wa Xian, Ph.D. observed as the p63+/Krt5+, which typically mature into the lungs’ alveoli, responded to lung damage caused by the H1N1 influenza virus by migrating to the sites of inflammation and restoring the lost tissue. Continue reading

Multiple Sclerosis Trial Exhibits Positive Results of Stem Cell Therapy.

A five year phase II clinical trial has shown initial success in treating multiple sclerosis.

In a recent update of an ongoing five year clinical trial conducted by the Chicago Blood Cancer Institute, patients with relapsing-remitting multiple sclerosis have experienced suppression of disease-related inflammation as a result of hematopoietic stem cell transplantations.  The stem cells have the ability to regulate the autoimmune attack on the central nervous system, and have provided 82.8% of the patients with two years thus far of event-free disease remission. Continue reading

In with a BAM – Stem Cells Advance Bladder Regeneration

The bladder acellular matrix is a housing of connective tissue that provides structural support for the functional cells of the bladder

New research from McGill University has shown that the bladder acellular matrix [BAM], or the external structure of connective tissue and growth factors that house the cellular components of the bladder, can serve as a scaffolding unit for mesenchymal stem cells [MSCs] to regenerate healthy bladder tissue.  The stem cells receive growth factors from the BAM, which direct them to differentiate into new bladder cells that, when transplanted into an animal model, exhibit nearly 100% normal bladder capacity and function. Continue reading

Bone Regeneration Technique Stimulates Stem Cells with Magnetic Nanoparticles.

Remote controlled nanoparticles may allow stem cells to regenerate bone tissue

Medical researchers from Keele University and Nottingham University have integrated remote controlled magnetic nanoparticles to incite the differentiation of stem cells into new bone tissue for the treatment of bone diseases, disorders, and injuries. In pre-clinical trials, the nanoparticles were coated with proteins that stimulate the stem cells, and then delivered directly to the damaged tissue via an external magnetic field. Continue reading