An Eye for a Tooth: Corneal Blindness Treatment Advances With The Use Of Dental Stem Cells.

Dental Stem Cells may hold the potential to cure corneal blindness.

Ophthalmologists James L Funderburgh, Ph.D. and Fatima Syed-Picard, Ph.D. from the University of Pittsburgh have devised a method for treating corneal blindness by utilizing dental pulp stem cells.  The researchers harvested the stem cells from molars discarded during routine extraction and induced the cells to differentiate into keratocytes [corneal cells].  They then seeded the cells onto a nanofiber scaffold, allowing them to grow into fully developed, functional corneas capable of restoring eyesight.    Continue reading

Stem Cells Make a ‘Dentin’ Tooth Decay.

Researchers have utilized low-intensity lasers to regenerate lost dentin in damaged teeth.

Researchers at the National Institute for Dental and Craniofacial Research have developed a method of utilizing autologous [the patient’s own] dental stem cells to regenerate damaged or decayed teeth.  In an animal model, as well as human cells in vitro [in a lab], the scientists treated the damaged teeth with low-intensity lasers, which prompted the stem cells located in the dental pulp to differentiate and grow into new, healthy dentin tissue. Continue reading

Genetic Diseases Decoded Utilizing Stem Cells

A new method of studying stem cells will lead to new translational genomics treatments for patients suffering from genetic diseases.

A team of Gladstone research scientists has utilized stem cells to develop a new gene-editing technique for inducing and studying rare genetic mutations linked to disease.   The technique, called TALENs, presents an opportunity for patients with genetic disorders to use their own stem cells to identify their specific genetic mutations. Continue reading

Dental Stem Cells Used to Study Neuropsychiatric Disorders

Stem Cells from teeth are integral in studying neuropsychiatric disorders.

In a recent study supported by the National Institutes of Health, stem cells extracted from baby teeth were differentiated into neural cells.  The success of the study demonstrates that teeth provide a non-invasive and accessible means for researchers to obtain and grow patient specific neural tissue to study autism spectrum disorders [ASD] and other neurological disorders.  This is in contrast to the recovery of stem cells from other sources – such as a skin biopsy, that are both invasive, more costly and less advantageous in the study of neural related disorders.  Continue reading

Stem Cell Diabetes Treatment Option Advances

doctor measuring patient's insulin level

In an early stage study recently carried out by the Institute of Kidney Diseases and Research Center (IKDRC), a treatment developed by the IKDRC utilizing Insulin Secreting Cells (ISC), derived from the patient’s own mesenchymal stem cells, shows that the need for insulin doses decreased by an average of 50% when the ISCs were implanted in patients.

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Advances in Stem Cell Therapy for Huntington’s Disease

Huntington's protein

Scientists at the University of California Davis’ Institute for Regenerative Cures are utilizing mesenchymal stem cells [the same type of stem cells found in teeth] to develop a new therapy that targets the genetic abnormality in Huntington’s disease. The principal investigator of the study, and the director of UC Davis stem cell program and the UC Davis Institute for Regenerative Cures, Jan Nolta said, “Our team has made a breakthrough that gives families affected by this disease hope that genetic therapy may one day become a reality.” The treatment seeks to address the root cause of the disease as opposed to merely mitigating the symptoms of the disease.

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Dental Pulp Stem Cells to Regenerate Teeth

Boy missing a tooth

Utilizing dental pulp stem cells, researchers at Japan’s National Center for Geriatrics and Gerontology have developed a stem cell treatment for tooth decay by restoring a tooth’s structure and function. In the study, involving canine subjects, researchers utilized the dog’s own dental pulp stem cells to repair damaged and compromised teeth.  Given the success of the study, researchers have initiated clinical [human] trials.

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Printing Bone Using Stem Cells; The Future of Regenerative Medicine is Now™

3D printed jawbone and skull scaffolds
Bone scaffolds

Researchers from University of Nottingham in England had their 3D printing technology on display last week at the Royal Society’s annual Summer Science Exhibition.  This technology is being used to create custom-fitted bone replacements and other body parts.

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WSJ Reports On Dental Stem Cells

Dental Pulp Stem Cells into muscle, nerve/spinal cord, bone, heart, liver, brain, skin (epithelial), ligaments & cartilage

Dental Pulp Stem Cells

 

 

 

 

 

 

 

 

 

The Wall Street Journal recently reported on current research involving dental pulp stem cells [DPSC].  Researchers worldwide, including StemSave’s Chief Scientific Adviser, Dr. Jeremy Mao of Columbia University, are making advances in restoring tooth tissue and regenerating entire teeth using dental pulp stem cells.  Current studies are in the animal model stage but researchers anticipate entering human clinical trials in the near future.

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