In a recent study conducted by the University Of Texas Southwestern Medical Center, scientists have discovered a rare line of stem cells involved in regulating spermatogenesis [the production of sperm cells]. Furthermore, these stem cells are resistant to chemotherapy and radiotherapy, which are toxic to the male germline and common causes for male infertility. Continue reading
Scientists have utilized stem cells to engineer an esophagus without exogenous growth factors.
Researchers from the Saban Research Institute of Children’s Hospital Los Angeles have grown esophageal tissue in vivo (in the body) from stem cells without the use of exogenous growth factors. In an animal model, the scientists transplanted stem cells, as well as a simple biodegradable scaffold, and relied on the stem cells’ ability to migrate towards the tissue in need of repair. The cells then differentiated into the epithelial, muscle, and nerve cells to develop a healthy esophagus. Continue reading
In a new study, researchers from the Singapore-MIT Alliance in Research and Technology have identified three physical characteristics of mesenchymal stem cells [MSCs] that can distinguish them from other bone marrow-derived cell types. By isolating cells in the bone marrow based on size, stiffness, and fluctuations in the nuclear membrane, scientists can rapidly generate and purify the stem cells needed to treat patients. Continue reading
Scientists from the National Institute of Neurological Disorders and Stroke have identified neural stem cells as important regulators of the olfactory bulb and its connections to the brain. The researchers discovered that a constant influx of stem cells is required for the olfactory system to function properly. The removal of stem cells causes a widespread disruption of signals sent to the brain, resulting in sensory deprivation. Continue reading
Researchers from the Indiana University School of Medicine have developed a potential therapy for peripheral artery disease by transplanting autologous [the patient’s own] stem cells. In an animal model, the transplanted stem cells differentiated into new blood vessels, which then restored blood flow to damaged tissues in the body. Continue reading
A team of bioengineers from Tel Aviv University is currently developing a scaffold to help regenerate heart muscle through the use of autologous stem cells. The scientists, led by Dr. Tal Dvir, aim to replace damaged cardiac tissue in heart attack patients by creating a scaffold out of collagen and gold nanoparticles, and then infusing it with the patient’s own stem cells to stimulate the rejuvenation of cardiomyocytes. Continue reading