In a pre-clinical trial, Researchers at the National University of Ireland Galway have found that mesenchymal stem cells (MSCs) demonstrate the ability to increase wound healing for diabetics’ related wounds. Diabetic patients have impaired ability to heal wounds with 25% of diabetic patients affected by foot ulcers; which may result in amputation.
Dr. Paolo Macchiarini and his team performed a windpipe transplant surgery at Children’s Hospital of Illinois on a 2 ½ year-old-girl born without a windpipe – a rare condition that is 99% fatal. Dr. Macchiarini grew the windpipe using a scaffold and the patient’s own stem cells. Hannah is the youngest person to ever receive a bioengineered organ. Dr. Macchiarini, who developed the pioneering treatment and has performed the surgery several times, said the treatment made him realize that the approach to building organs may work best with children by harnessing their natural ability to grow and heal.
The world of regenerative medicine is advancing rapidly, as more complex organs are being grown and transplanted. Recently, researchers, supported by the Biomedical Research Center at the University College London Hospitals, have been awarded the funding to conduct the first-ever clinical trial of a stem cell generated voice box transplant. The creation of a voice box represents the evolution of the successful creation and transplantation of an artificial trachea as researchers and scientist develop the capability of growing ever more complex organs.
In a follow-up study, stem cells from teeth were found to provide a viable and stable repair mechanism for mandibular bone defects. Three years after the clinical trial was initiated, the bone is still functioning properly.